Neural Circuit Organization

The complexity of operations performed by the cerebellum will depend, in part, on the diversity of the neurons that compose its cortex and the logic of their connectivity onto one another. Therefore, we are profiling cerebellar neurons to identify genetically defined neuron types and using ultrastructural reconstructions and functional recordings to uncover connectivity motifs that support distinct computational operations relevant for learning.

Chemogenetic disinhibition of climbing-fiber-evoked calcium activity in Purkinje cell dendrites during behavior.

Chemogenetic disinhibition of climbing-fiber-evoked calcium activity in Purkinje cell dendrites during behavior.

Tools to target cell types.

Tools to target cell types.